Caries-risk Assessment and Management for Infants, Children, and Adolescents
The American Academy of Pediatric Dentistry (AAPD) recognizes that caries-risk assessment and management protocols can assist clinicians with decisions regarding treatment based upon caries risk and patient compliance and are essential elements of contemporary clinical care for infants, children, and adolescents. These recommendations are intended to educate healthcare providers and other interested parties on the assessment of caries risk in contemporary pediatric dentistry and aid in clinical decision making regarding diagnostic, fluoride, dietary, and restorative protocols.
This document was developed by the Council on Clinical Affairs and adopted in 2002. This document is an update of AAPD’s Policy on Use of a Caries-risk Assessment Tool (CAT) for Infants, Children, and Adolescents, revised in 2006 that includes the additional concepts of dental caries management protocols. The update used electronic and hand searches of English written articles in the medical and dental literature within the last 10 years using the search terms caries risk assessment, caries management, and caries clinical protocols. From this search, 1,909 articles were evaluated by title or by abstract. Information from 75 articles was used to update this document. When data did not appear sufficient or were inconclusive, recommendations were based upon expert and/or consensus opinion by experienced researchers and clinicians.
Risk assessment procedures used in medical practice normally have sufficient data to accurately quantitate a person’s disease susceptibility and allow for preventive measures.1 Even though caries-risk data in dentistry still are not sufficient to quantitate the models, the process of determining risk should be a component in the clinical decision-making process.2 Risk assessment:
- fosters the treatment of the disease process instead of treating the outcome of the disease
- gives an understanding of the disease factors for a specific patient and aids in individualizing preventive discussions.
- individualizes, selects, and determines frequency of preventive and restorative treatment for a patient.
- anticipates caries progression or stabilization.
Caries-risk assessment models currently involve a combination of factors including diet, fluoride exposure, a susceptible host, and microflora that interplay with a variety of social, cultural, and behavioral factors.3-6 Caries risk assessment is the determination of the likelihood of the incidence of caries (i.e., the number of new cavitated or incipient lesions) during a certain time period7 or the likelihood that there will be a change in the size or activity of lesions already present. With the ability to detect caries in its earliest stages (i.e., white spot lesions), health care providers can help prevent cavitation.8-10
Caries risk indicators are variables that are thought to cause the disease directly (e.g., microflora) or have been shown useful in predicting it (e.g., socioeconomic status) and include those variables that may be considered protective factors. Currently, there are no caries-risk factors or combinations of factors that have achieved high levels of both positive and negative predictive values.2 Although the best tool to predict future caries is past caries experience, it is not particularly useful in young children due to the importance of determining caries risk before the disease is manifest. Children with white spot lesions should be considered at high risk for caries since these are precavitated lesions that are indicative of caries activity.11 Plaque accumulation also is strongly associated with caries development in young children.12,13 As a corollary to the presence of plaque,14 a child’s Mutans streptococci (MS) levels3 and the age at which a child becomes colonized with cariogenic flora15,16 are valuable in assessing risk, especially in preschool children.
While there is no question that fermentable carbohydrates are a necessary link in the causal chain for dental caries, a systematic study of sugar consumption and caries risk has concluded that the relationship between sugar consumption and caries is much weaker in the modern age of fluoride exposure than previously thought.17 However, there is evidence that night-time use of the bottle, especially when it is prolonged, may be associated with early childhood caries.18 Despite the fact that normal salivary flow is an extremely important intrinsic host factor providing protection against caries, there is little data about the prevalence of low salivary flow in children.19,20
Sociodemographic factors have been studied extensively to determine their effect on caries risk. Children with immigrant backgrounds have three times higher caries rates than nonimmigrants.21 Most consistently, an inverse relationship between socioeconomic status and caries prevalence is found in studies of children less than six years of age.22 Perhaps another type of sociodemographic variable is the parents’ history of cavities and abscessed teeth; this has been found to be a predictor of treatment for early childhood caries.23,24
The most studied factors that are protective of dental caries include systemic and topical fluoride, sugar substitutes, and tooth brushing with fluoridated toothpaste. Teeth of children who reside in a fluoridated community have been shown to have higher fluoride content than those of children who reside in suboptimal fluoridated communities.25 Additionally, both pre- and post-eruption fluoride exposure maximize the caries-preventive effects.26,27 For individuals residing in nonfluoridated communities, fluoride supplements have shown a significant caries reduction in primary and permanent teeth.28 With regard to fluoridated toothpaste, studies have shown consistent reduction in caries experience.29 Professional topical fluoride applications performed semiannually also reduce caries,30 and fluoride varnishes generally are equal to that of other professional topical fluoride vehicles.31
The effect of sugar substitutes on caries rates have been evaluated in several populations with high caries prevalence.32 Studies indicate that xylitol can decrease MS levels in plaque and saliva and can reduce dental caries in young children and adults, including children via their mothers.33 With regard to toothbrushing, there only is a weak relationship between frequency of brushing and decreased dental caries, which is confounded because it is difficult to distinguish whether the effect is actually a measure of fluoride application or whether it is a result of mechanical removal of plaque.34 The dental home or regular periodic care by the same practitioner is included in many caries-risk assessment models because of its known benefit for dental health.35
Risk assessment tools can aid in the identification of reliable predictors and allow dental practitioners, physicians, and other nondental health care providers to become more actively involved in identifying and referring high-risk children. Tables 1, 2, and 3 incorporate available evidence into practical tools to assist dental practitioners, physicians, and other non-dental health care providers in assessing levels of risk for caries development in infants, children, and adoles cents. As new evidence emergences, these tools can be refined to provide greater predictably of caries in children prior to disease initiation. Furthermore, the evolution of caries-risk assessment tools and protocols can assist in providing evidence for and justifying periodicity of services, modification of third-party involvement in the delivery of dental services, and quality of care with outcomes assessment to address limited resources and work-force issues.
Caries management protocols
Clinical management protocols are documents designed to assist in clinical decision-making; they provide criteria regarding diagnosis and treatment and lead to recommended courses of action. The protocols are based on evidence from current peer-reviewed literature and the considered judgment of expert panels, as well as clinical experience of practitioners. The protocols should be updated frequently as new technologies and evidence develop.
Historically, the management of dental caries was based on the notion that it was a progressive disease that eventually destroyed the tooth unless there was surgical/restorative intervention. Decisions for intervention often were learned from unstandardized dental school instruction, and then refined by clinicians over years of practice. Little is known about the criteria dentists use when making decisions involving restoration of carious lesions.36
It is now known that surgical intervention of dental caries alone does not stop the disease process. Additionally, many lesions do not progress, and tooth restorations have a finite longevity. Therefore, modern management of dental caries should be more conservative and includes early detection of noncavitated lesions, identification of an individual’s risk for caries progression, understanding of the disease process for that individual, and active surveillance to apply preventive measures and monitor carefully for signs of arrestment or progression.
Caries management protocols for children further refine the decisions concerning individualized treatment and treatment thresholds based on a specific patient’s risk levels, age, and compliance with preventive strategies (Tables 4, 5, 6). Such protocols should yield greater probability of success and better cost effectiveness of treatment than less standardized treatment. Additionally, caries management protocols free practitioners of the necessity for repetitive high level treatment decisions, standardize decision making and treatment strategies,36-38 eliminate treatment uncertainties, and guarantee more correct strategies.39
Content of the present caries management protocol is based on results of clinical trials, systematic reviews, and expert panel recommendations that give better understanding of and recommendations for diagnostic, preventive, and restorative treatments. The radiographic diagnostic guidelines are based on the latest guidelines from the American Dental Association (ADA).40 Systemic fluoride protocols are based on the Centers for Disease Control and Prevention’s (CDC) recommendations for using fluoride.29 Guidelines for the use of topical fluoride treatment are based on the ADA’s Council on Scientific Affairs’ recommendations for use of fluoride toothpaste in young children41 and professionally applied and prescription strength home-use topical fluoride,42 and the CDC’s fluoride guidelines.29 Guidelines for pit and fissure sealants are based on the ADA’s Council on Scientific Affairs recommendations for the use of pit-and-fissure sealants.43 Guidelines on diet counseling to prevent caries are based on two review papers.44,45 Guidelines for the use of xylitol are based on the AAPD’s oral health policy on use of xylitol in caries prevention,32 a wellexecuted clinical trial on high caries-risk infants and toddlers,46 and two evidence-based reviews.47,48 Active surveillance (prevention therapies and close monitoring) of enamel lesions is based on the concept that treatment of disease may only be necessary if there is disease progression,49 that caries progression has diminished over recent decades,50 and that the majority of proximal lesions, even in dentin, are not cavitated.51 Other approaches to the assessment and treatment of dental caries will emerge with time and, with evidence of effectiveness, may be included in future guidelines on caries-risk assessment and management protocols. For example, there are emerging trends to use calcium and phosphate remineralizing solution to reverse dental caries.52
Other fluoride compounds, such as silver diamine fluoride53 and stannous fluoride54, may be more effective than sodium fluoride for topical applications. There has been interest in antimicrobials to affect the caries rates, but evidence from caries trials is still inconclusive.55,56 However, some other proven methods, such as prescription fluoride drops and tablets, may be removed from this protocol in the future due to attitudes, risks, or compliance.57,58
- Dental caries-risk assessment, based on a child’s age, biological factors, protective factors, and clinical findings, should be a routine component of new and periodic examinations by oral health and medical providers.
- While there is not enough information at present to have quantitative caries-risk assessment analyses, estimating children at low, moderate, and high caries risk by a preponderance of risk and protective factors will enable a more evidence-based approach to medical provider referrals, as well as establish periodicity and intensity of diagnostic, preventive, and restorative services.
- Clinical management protocols, based on a child’s age, caries risk, and level of patient/parent cooperation, provide health providers with criteria and protocols for determining the types and frequency of diagnostic, preventive, and restorative care for patient specific management of dental caries.
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- Litt MD, Reisine S, Tinanoff N. Multidimensional causal model of dental caries development in low-income preschool children. Public Health Reports 1995;110(4):607-17.
- Nicolau B, Marcenes W, Bartley M, Sheiham A. A life ourse approach to assessing causes of dental caries experience: The relationship between biological, behavioural, socio-economic and psychological conditions and caries in adolescents. Caries Res 2003;37(5):319-26.
- Featherstone JD. The caries balance: Contributing factors and early detection. J Calif Dent Assoc 2003;31(2):129-33.
- Featherstone JD. The caries balance: The basis for caries management by risk assessment. Oral Health Prev Dent 2004;2(Suppl 1):259-64.
- Reich E, Lussi A, Newbrun E. Caries-risk assessment. Int Dent J 1999;49(1):15-26.
- Ismail AI, Nainar SM, Sohn W. Children’s first dental visit: Attitudes and practices of US pediatricians and family physicians. Pediatr Dent 2003;25(5):425-30.
- Tsang P, Qi F, Shi W. Medical approach to dental caries: Fight the disease, not the lesion. Pediatr Dent 2006;28(2):188-98.
- Crall JJ. Development and integration of oral health services for preschool-age children. Pediatr Dent 2005;27(4):323-30.
- Vadiakas G. Case definition, aetiology and risk assessment of early childhood caries (ECC): A revisited review. European Arch Paed Dent 2008;9(9):114-25.
- Alaluusua S, Malmivirta R. Early plaque accumulation – A sign for caries risk in young children. Community Dent Oral Epidemiol 1994;22(10):273-6.
- Roeters J, Burgesdijk R, Truin GJ, van ’t Hof M. Dental caries and its determinants in 2- to-5-year old children. ASDC J Dent Child 1995;62(6):401-8.
- Lee C, Tinanoff N, Minah G, Romberg E. Effect of Mutans streptococcal colonization on plaque formation and regrowth in young children – A brief communication. J Public Health Dent 2008;68(1):57-60.
- Thibodeau EA, O’Sullivan DM, Tinanoff N. Mutans streptococci and caries prevalence in preschool children. Community Dent Oral Epidemiol 1993;21(5):288-91.
- Grindefjord M, Dahllöf G, Nilsson B, Modéer T. Prediction of dental caries development in 1-year old children. Caries Res 1995;29(5):343-8.
- Burt BA, Satishchandra P. The relationship between low birthweight and subsequent development of caries: A systematic review. J Dent Ed 2001;65(10):1017-23.
- Reisine S, Douglass JM. Psychosocial and behavioral issues in early childhood caries. Community Dent Oral Epidemiol 1998;26(1 Suppl):45-8.
- Cataldo WL, Oppenheim FG. Physical and chemical aspects of saliva as indicators of risk for dental caries in humans. J Dent Ed 2001;65(10):1054-62.
- Vanobbergen J, Martens L, Lesaffre E, Bogaerts K, Declerck D. The value of a baseline caries risk assessment model in the primary dentition for the prediction of caries increment in the permanent dentition. Caries Res 2001;35(6):442-50.
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- Vargas CM, Crall JJ, Schneider DA. Sociodemographic distribution of pediatric dental caries: NHANES III, 1988-1994. J Am Dent Assoc 1998;129(9):1229-38.
- Southward LH, Robertson A, Edelstein BL, et al. Oral health of young children in Mississippi Delta child care centers: A second look at early childhood caries risk assessment. J Public Health Dent 2008;68(4):188-95.
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- Beltrán-Aguilar ED, Goldstein JW, Lockwood SA. Fluoride varnishes: A review of their clinical use, cariostatic mechanism, efficacy and safety. J Am Dent Assoc 2000;131(5):589-96.
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